This course is an introduction to the “tree of life” (phylogeny): its conceptual origins, methods for discovering its structure, how phylogenies are used in macroevolution, and its importance in evolutionary biology and other areas of science. Topics include historical context and concepts, sources of data, methods of phylogenetic analysis, and the use of phylogenies to study systematics and classification, the tempo and mode of lineage diversification, coevolution, biogeography, conservation, molecular biology, development, and epidemiology.